Bernhard Hube Selected Research

Aspartic Acid Proteases

10/2016	In vivo induction of neutrophil chemotaxis by secretory aspartyl proteinases of Candida albicans.
6/2015	Secretory Aspartyl Proteinases Cause Vaginitis and Can Mediate Vaginitis Caused by Candida albicans in Mice.
11/2008	Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis.
8/2007	The role of secreted aspartyl proteinases in Candida albicans keratitis.
5/2005	Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis.
6/2003	The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium.

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Bernhard Hube Research Topics

Disease

57	Infections 01/2022 - 04/2001
11	Candidiasis (Moniliasis) 01/2021 - 06/2003
7	Starvation 10/2021 - 04/2005
6	Inflammation (Inflammations) 01/2021 - 10/2013
5	Mycoses (Diseases, Fungus) 01/2021 - 06/2003
5	Oral Candidiasis (Thrush) 01/2020 - 12/2007
3	Necrosis 10/2021 - 09/2004
3	Hypersensitivity (Allergy) 12/2020 - 04/2007
3	Vulvovaginal Candidiasis 01/2018 - 10/2013
2	Mitochondrial Diseases (Mitochondrial Disease) 10/2021 - 01/2021
2	Sepsis (Septicemia) 12/2020 - 01/2018
2	Vaginitis 10/2016 - 06/2015
1	Disease Progression 01/2022
1	Mucormycosis 01/2021
1	Rupture 12/2020
1	Liver Diseases (Liver Disease) 01/2020
1	Alcoholic Hepatitis 01/2020
1	Iron Deficiencies 01/2017
1	Candidemia 01/2016
1	Hereditary Complement Deficiency Diseases 04/2012
1	Juvenile Amyotrophic Lateral Sclerosis 2 01/2011
1	Tissue Adhesions 12/2009
1	Hemolysis 12/2009
1	Keratitis 08/2007

Drug/Important Bio-Agent (IBA)

14	Peptide Hydrolases (Proteases)FDA Link 01/2018 - 04/2002
12	Candida albicans ECE1 proteinIBA 01/2022 - 04/2016
9	CytokinesIBA 10/2020 - 04/2002
7	Peptides (Polypeptides)IBA 01/2022 - 01/2013
7	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2002
6	ChemokinesIBA 01/2019 - 04/2002
6	Aspartic Acid ProteasesIBA 10/2016 - 06/2003
5	Virulence Factors (Pathogenicity Factors)IBA 01/2021 - 04/2002
5	MicronutrientsIBA 01/2017 - 09/2014
4	InflammasomesIBA 12/2020 - 06/2015
4	IronIBA 01/2017 - 11/2008
3	Transcription Factors (Transcription Factor)IBA 01/2017 - 08/2009
3	Clotrimazole (Lotrimin)FDA LinkGeneric 07/2015 - 09/2011
3	NitrogenIBA 09/2014 - 04/2005
2	Adenosine Triphosphate (ATP)IBA 10/2021 - 12/2020
2	RNA (Ribonucleic Acid)IBA 01/2021 - 10/2020
2	Anti-Bacterial Agents (Antibiotics)IBA 12/2020 - 07/2014
2	C-Type Lectins (C-Type Lectin)IBA 01/2020 - 01/2019
2	GlucansIBA 01/2020 - 01/2012
2	Interleukin-6 (Interleukin 6)IBA 12/2016 - 09/2004
2	Interleukin-8 (Interleukin 8)IBA 12/2016 - 09/2004
2	EnzymesIBA 10/2016 - 04/2007
2	AntibodiesIBA 01/2016 - 06/2015
2	AntigensIBA 06/2015 - 06/2003
2	CarbohydratesIBA 01/2012 - 04/2005
2	Messenger RNA (mRNA)IBA 04/2002 - 04/2001
1	Autophagy-Related ProteinsIBA 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 10/2021
1	AlbuminsIBA 01/2021
1	Serum AlbuminIBA 01/2021
1	RicinIBA 01/2021
1	mucoricinIBA 01/2021
1	Interferon Type IIBA 01/2021
1	Fluconazole (Zonal)FDA LinkGeneric 01/2021
1	ErbB Receptors (EGF Receptor)IBA 12/2020
1	Antimicrobial PeptidesIBA 01/2020
1	Ethanol (Ethyl Alcohol)IBA 01/2020
1	Biotin (Vitamin H)FDA Link 01/2020
1	HistatinsIBA 01/2020
1	ExotoxinsIBA 01/2020
1	VitaminsIBA 01/2020
1	Pathogen-Associated Molecular Pattern MoleculesIBA 01/2019
1	Syk KinaseIBA 01/2019
1	PotassiumIBA 10/2018
1	Interleukin-1 (Interleukin 1)IBA 01/2018
1	Interleukin-23 (Interleukin 23)IBA 01/2018
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 11/2017
1	Interleukin-17 (Interleukin 17)IBA 11/2017
1	FarnesolIBA 01/2017
1	PeptonesIBA 01/2016
1	Protease Inhibitors (Protease Inhibitor)IBA 06/2015
1	pepstatin (pepstatin A)IBA 06/2015
1	VaccinesIBA 06/2015
1	Purine NucleotidesIBA 01/2015
1	GuanineIBA 01/2015
1	CarbonIBA 09/2014
1	Arginine (L-Arginine)FDA Link 01/2014
1	Bovine Serum AlbuminIBA 01/2014
1	Amino Acids FDA Link 01/2014
1	Amino Acid Transport Systems (Amino Acid Transporter)IBA 01/2014
1	Complement Membrane Attack Complex (Membrane Attack Complex)IBA 04/2012
1	Fungal RNAIBA 01/2012
1	glyoxylic acid (glyoxylate)IBA 01/2012
1	bifonazoleIBA 09/2011
1	Antifungal AgentsIBA 09/2011
1	Interleukin-10 (Interleukin 10)IBA 01/2011
1	Pharmaceutical PreparationsIBA 11/2010
1	Complement System Proteins (Complement)IBA 12/2009
1	Iron-Binding ProteinsIBA 11/2008
1	Chelating AgentsIBA 04/2007
1	Caffeine (No Doz)FDA LinkGeneric 04/2007

Therapy/Procedure

3	Therapeutics 01/2020 - 04/2002
1	Central Venous Catheters 12/2020
1	Liver Transplantation 01/2020
1	Transcutaneous Electric Nerve Stimulation (TENS) 12/2019
1	Transjugular Intrahepatic Portasystemic Shunt 01/2012